From the Ayalon Highway:

Exit at La Guardia intersection, to the west (towards central Tel Aviv), straight to Harakkevet St. Continue through to Yehuda Halevi St. Turn right to Yavne St. Take the second turn right to Ahad Ha’am Street. The TASE building is at number 54, on the right hand side (second building).

From Ibn Gevirol Street:

Driving south, continue onto Yehuda Halevi St. Turn right to Yavne St. Take the second turn right to Ahad Ha’am Street. The TASE building is at number 54, on the right hand side (second building).